Abstract
Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Chemistry, Pharmaceutical
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Choline / analogs & derivatives*
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Choline / chemistry
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Choline / pharmacology
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Drug Design
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Ethers / chemistry
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Ethylamines / chemistry*
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Kinetics
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Models, Chemical
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Nicotinic Antagonists / pharmacology
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Pyridines / chemistry*
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Pyridines / pharmacology
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Receptors, Nicotinic / chemistry*
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Temperature
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alpha7 Nicotinic Acetylcholine Receptor
Substances
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3-(2-(N,N,N-trimethylammonium)ethoxy)pyridine
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Ethers
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Ethylamines
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Nicotinic Antagonists
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Pyridines
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Receptors, Nicotinic
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alpha7 Nicotinic Acetylcholine Receptor
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Choline